Key result
Lower SDNN links to increased risk of major events in idiopathic dilated cardiomyopathy.
Why the study?
Does impaired cardiac autonomic control (HRV and HRT) predict adverse clinical outcomes and correlate with prognostic markers in patients with idiopathic dilated cardiomyopathy?
Observational (n=89)
No
Does impaired cardiac autonomic control (HRV and HRT) predict adverse clinical outcomes and correlate with prognostic markers in patients with idiopathic dilated cardiomyopathy?
Effect estimate: OR 0.966 (95% CI 0.940-0.993)
p-value: p=0.014
Impaired cardiac autonomic control, as measured by reduced heart rate variability, correlates with established prognostic markers and predicts adverse long-term clinical outcomes in patients with idiopathic dilated cardiomyopathy.
No takes yet. Share an insight, caveat, or question.
May refine risk stratification in idiopathic dilated cardiomyopathy; hypothesis-generating pending prospective validation.
Kärkkäinen et al. (2015) conducted an observational in Idiopathic Dilated Cardiomyopathy (n=89). Attenuated Heart Rate Variability vs. Preserved Heart Rate Variability was evaluated on Combined clinical endpoint (death, heart transplantation, and implantation of an automatic cardioverter defibrillator and/or a biventricular pacemaker) (OR 0.966, 95% CI 0.940-0.993, p=0.014). In patients with idiopathic dilated cardiomyopathy, attenuated heart rate variability (lower SDNN) was significantly associated with an increased risk of death, heart transplantation, or device implantation.
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