Key result
Gender differences exist in electrical therapies, with women referred later for catheter ablation but showing greater response to cardiac resynchronization therapy compared to men.
Why the study?
How does gender affect procedural considerations, results, and complications of electrical therapies for the heart?
How does gender affect procedural considerations, results, and complications of electrical therapies for the heart?
This review highlights significant gender-related differences in referral patterns, procedural outcomes, and complications for cardiac electrical therapies, emphasizing the need for gender-specific considerations.
Answers are grounded in this paper and cite their sources.
Gender differences in ablation referral timing and CRT response warrant consideration; leaves open need for prospective validation.
Use of cardiac implantable devices and catheter ablation is steadily increasing in Western countries following the positive results of clinical trials. Despite the advances in scientific knowledge, tools development, and techniques improvement we still have some grey area in the field of electrical therapies for the heart. In particular, several reports highlighted differences both in medical behaviour and procedural outcomes between female and male candidates. Women are referred later for catheter ablation of supraventricular arrhythmias, especially atrial fibrillation, leading to suboptimal results. On the opposite females present greater response to cardiac resynchronization, while the benefit of implantable defibrillator in primary prevention seems to be less pronounced. Differences on aetiology, clinical profile, and development of myocardial scarring are the more plausible causes. This review will discuss all these aspects together with gender-related differences in terms of acute/late complications. We will also provide useful hints on plausible mechanisms and practical procedural aspects.
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Diemberger et al. (2017) conducted a review in Cardiac arrhythmias and heart failure requiring electrical therapies. Cardiac implantable devices and catheter ablation vs. Male vs Female was evaluated. Gender differences exist in electrical therapies, with women referred later for catheter ablation but showing greater response to cardiac resynchronization therapy compared to men.
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