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April 13, 2023Open Access

Female sex carries similar arrhythmia recurrence and complication risks as males after AF ablation.

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Why the study?

Most prior studies of AF catheter ablation outcomes included relatively small female cohorts, leaving the impact of sex on procedural safety and outcomes unclear.

Does female sex compared to male sex affect arrhythmia recurrence and procedural complications in patients undergoing first catheter ablation for atrial fibrillation?

Population

1346 patients undergoing first catheter ablation for AF

Comparison

Female patients vs male patients

Design

Retrospective study

Follow-up

1-y

Key result

Female sex was associated with similar 1-year arrhythmia recurrence rates (30% vs 27.7%; p=0.38) and procedural complications (3.1% vs 1.8%; p=0.56) compared to male sex after AF catheter ablation.

Authors

RYRitu YadavJMJenna MilsteinJBJacob Blum

Discussion

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Member takes

Overview

Supports comparable AF ablation outcomes by sex; extends observational data but leaves causal effects open.

Study Design

Type

Cohort (n=1,346)

Structured PICO

Does female sex compared to male sex affect arrhythmia recurrence and procedural complications in patients undergoing first catheter ablation for atrial fibrillation?

P
Population
1,346 patients undergoing first catheter ablation for atrial fibrillation, including 896 (66.5%) male and 450 (33.4%) female patients.
I
Intervention
Catheter ablation for atrial fibrillation in female patients
C
Comparator
Catheter ablation for atrial fibrillation in male patients
O
Outcome
Arrhythmia recurrence at 1-year post ablation and procedural complication rate

Main Result

Absolute Event Rate: 30% vs 27.7%

p-value: p=0.38

Despite women being older and having higher CHA2DS2-VASc scores at the time of AF ablation, there are no significant sex-based differences in 1-year arrhythmia recurrence or procedural complications.

Cite This Study

Yadav et al. (2023) conducted a cohort in Atrial fibrillation (n=1,346). Female sex vs. Male sex was evaluated on Arrhythmia recurrence at 1-year post ablation (p=0.38). Female sex was associated with similar 1-year arrhythmia recurrence rates (30% vs 27.7%; p=0.38) and procedural complications (3.1% vs 1.8%; p=0.56) compared to male sex after AF catheter ablation.

synapsesocial.com/papers/6a11d6ea8095bbd48eb4caaahttps://doi.org/10.22541/au.168136027.76776769/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gender Differences in the Risk of Ischemic Stroke and Peripheral Embolism in Atrial Fibrillation2005 · 477 citations
  2. 2Association of Atrial Tissue Fibrosis Identified by Delayed Enhancement MRI and Atrial Fibrillation Catheter Ablation2014 · 1,451 citations
  3. 3Early Rhythm-Control Therapy in Patients with Atrial Fibrillation2020 · 2,199 citations
  4. 4Sex-related differences in catheter ablation of atrial fibrillation: a systematic review and meta-analysis2019 · 89 citations
  5. 5Sex difference in atrial fibrillation recurrence after catheter ablation and antiarrhythmic drugs2022 · 40 citations