Gender differences in patients with structural heart disease undergoing VT ablation
Key result
Female patients undergoing VT ablation had similar rates of VT noninducibility (p=0.844), major complications (p=0.719), and overall mortality (p=0.176) compared to male patients.
Why the study?
Female patients are often underrepresented in large studies despite documented differences in clinical presentation, treatment, and prognosis, prompting this examination of gender differences in patients with structural heart disease undergoing VT ablation.
Does gender affect the clinical presentation, procedural characteristics, and outcomes of VT ablation in patients with structural heart disease?
Population
88 female patients and 88 male patients with structural heart disease undergoing VT ablation
Comparison
Female patients vs male patients
Design
Case-control study
Authors
Discussion
Loading...
Member takes
Implication
May support uniform VT ablation strategies regardless of sex; leaves open dedicated trials on gender differences in arrhythmogenic substrate.
Study Design
Type
Case-Control (n=176)
Structured PICO
Does gender affect the clinical presentation, procedural characteristics, and outcomes of VT ablation in patients with structural heart disease?
P
Population
176 patients (88 female, 88 male) with structural heart disease undergoing ventricular tachycardia ablation.
E
Exposure
Ventricular tachycardia (VT) ablation in female patients
C
Comparator
Ventricular tachycardia (VT) ablation in male patients (case-control matching)
O
Outcome
Procedural acute results (VT noninducibility), major procedure-related complications, freedom from VT during follow-up, and overall mortalityhard clinical
Main Result
p-value: p=.844
Despite presenting with more arrhythmogenic substrate and less optimized heart failure therapy, female patients with structural heart disease undergoing VT ablation achieve similar acute and long-term outcomes as male patients.
Cite This Study
Darma et al. (2021) conducted a case-control in Structural heart disease with ventricular tachycardia (n=176). Female gender vs. Male gender was evaluated on VT noninducibility as ablation endpoint (p=.844). Female patients undergoing VT ablation had similar rates of VT noninducibility (p=0.844), major complications (p=0.719), and overall mortality (p=0.176) compared to male patients.