Key result
Rapid ventricular pacing-induced congestive heart failure (after 20 +/- 7 days) enhanced the inducibility of sustained atrial tachycardia (cycle length 120 +/- 12 msec) in dogs.
Why the study?
Does rapid ventricular pacing-induced CHF promote the inducibility of sustained atrial tachycardia in dogs?
Population
18 dogs with congestive heart failure (CHF) and atrial enlargement induced by rapid ventricular pacing
Comparison
Rapid ventricular pacing at 235 beats/min to… vs Baseline state in all dogs, and recovery from…
Design
Preclinical
Follow-up
20 +/- 7 days
Authors
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Animal data link heart failure to atrial tachycardia inducibility; leaves open clinical translation and mechanisms in humans.
Does rapid ventricular pacing-induced CHF promote the inducibility of sustained atrial tachycardia in dogs?
CHF induced by rapid ventricular pacing in dogs promotes sustained atrial tachycardia, likely driven by delayed afterdepolarizations and intracellular calcium overload.
Stambler et al. (2003) studied Congestive heart failure and atrial tachycardia (n=18). Rapid ventricular pacing vs. Baseline (pre-pacing) and recovery was evaluated on Inducibility of sustained atrial tachycardia. Rapid ventricular pacing-induced congestive heart failure (after 20 +/- 7 days) enhanced the inducibility of sustained atrial tachycardia (cycle length 120 +/- 12 msec) in dogs.
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