Key result
Pacing of isolated sheep right atria at frequencies at or above approximately 6.5 Hz led to spatially distributed intermittent blockade and disorganized wave propagation (fibrillatory conduction).
Population
Isolated, coronary-perfused sheep right atrium
Design
Preclinical
Authors
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May explain AF complexity via branch-point conduction block; extends mechanistic models but leaves human translation open.
High-frequency activation from the left atrium can undergo fibrillatory conduction toward the right atrium, with sink-to-source effects at branch points determining arrhythmia complexity.
Berenfeld et al. (2002) studied Atrial fibrillation. Rhythmic pacing of Bachmann's bundle was evaluated on Wave propagation and activation delays. Pacing of isolated sheep right atria at frequencies at or above approximately 6.5 Hz led to spatially distributed intermittent blockade and disorganized wave propagation (fibrillatory conduction).
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