November 15, 1996Circulation
Incomplete Reentry and Epicardial Breakthrough Patterns During Atrial Fibrillation in the Sheep Heart
Key result
Video imaging of Langendorff-perfused sheep hearts (n=6) revealed that atrial fibrillation activation (average period 138 ms) involves incomplete reentry and breakthrough patterns every 215 ms.
Population
Langendorff-perfused sheep hearts and a computer model of atrial free wall connected to a pectinate muscle
Design
Preclinical
Authors
Discussion
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Implication
Suggests subendocardial networks drive AF breakthroughs; hypothesis-generating for human ablation targets.
Structured PICO
P
Population
Langendorff-perfused sheep hearts (n=6) and a computer model of atrial free wall connected to a pectinate muscle
I
Intervention
Pacing to initiate atrial fibrillation
O
Outcome
Sequence of activation on the surface of the right atrium and patterns of wave propagation during initiation and maintenance of atrial fibrillationsurrogate
The complex three-dimensional structure of the atria, particularly subendocardial muscle networks, plays a major role in the activation sequences and epicardial breakthrough patterns during atrial fibrillation.
Cite This Study
Gray et al. (1996) studied Atrial fibrillation (n=6). Video imaging and transmembrane potential recording was evaluated on Patterns of wave propagation and activation sequences. Video imaging of Langendorff-perfused sheep hearts (n=6) revealed that atrial fibrillation activation (average period 138 ms) involves incomplete reentry and breakthrough patterns every 215 ms.