February 26, 2015Circulation Arrhythmia and ElectrophysiologyOpen Access

Quantification of the Transmural Dynamics of Atrial Fibrillation by Simultaneous Endocardial and Epicardial Optical Mapping in an Acute Sheep Model

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Population

Ovine isolated left atria (acute sheep model)

Comparison

Simultaneous endocardial and epicardial optical… vs Paced rhythms

Design

Preclinical

Authors

SGSarah R. GutbrodBoston Scientific (United States)RWRichard D. WaltonUniversité de Bordeaux SGStephen GilbertElse Kröner-Fresenius-Stiftung

Discussion

Member takes

Implication

Transmural discordance may limit 2D mapping accuracy; leaves open whether 3D approaches improve AF ablation outcomes.

Structured PICO

Population

Ovine isolated left atria (acute sheep model)

Intervention

Simultaneous endocardial and epicardial optical mapping during acute fibrillation

Comparator

Paced rhythms

Outcome

Synchrony of activation patterns (dominant frequency, regularity index, propagation angles, and phase dynamics) across imaging planessurrogate

Optical mapping in an ovine model demonstrates significant transmural discordance in electrical activity during atrial fibrillation, highlighting the 3-dimensional complexity of AF substrates.

Cite This Study

Gutbrod et al. (2015) studied this question.

synapsesocial.com/papers/6a73db1d43194bd21bf15d2c https://doi.org/10.1161/circep.114.002545

Topics

Atrial fibrillation Persistent AF management AF ablation outcomes

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Quantification of the Transmural Dynamics of Atrial Fibrillation by Simultaneous Endocardial and Epicardial Optical Mapping in an Acute Sheep Model

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Quantification of the Transmural Dynamics of Atrial Fibrillation by Simultaneous Endocardial and Epicardial Optical Mapping in an Acute Sheep Model

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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