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June 1, 2002Journal of Cardiovascular Electrophysiology

Simultaneous Biatrial Computerized Mapping During Permanent Atrial Fibrillation in Patients with Organic Heart Disease

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Key result

Simultaneous biatrial mapping during permanent AF showed a shorter mean activation cycle length in the left atrial posterior wall than the right atrial free wall (179 vs 196 msec; P=0.004).

Why the study?

Does the left atrial posterior wall exhibit different activation patterns compared to the right atrial free wall during permanent AF in patients with organic heart disease?

Population

6 patients with permanent atrial fibrillation and organic heart diseases undergoing surgery. Mean duration…

Comparison

Simultaneous computerized epicardial mapping of… vs Intra-patient comparison between right atrial…

Design

Case_series

Authors

TWTsu-Juey WuNational Yang Ming Chiao Tung UniversityRDRahul N. DoshiElectrophysiologyHHHaitian HuangCedars-Sinai Medical Center

Discussion

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Implication

Indicates possible LAPW driver role in permanent AF; leaves open whether targeted ablation improves outcomes.

Study Design

Type

Observational (n=6)

Structured PICO

Does the left atrial posterior wall exhibit different activation patterns compared to the right atrial free wall during permanent AF in patients with organic heart disease?

P
Population
6 patients with permanent atrial fibrillation (AF) and organic heart diseases undergoing surgery. Mean duration of AF 4.9+/-7.6 years.
I
Intervention
Simultaneous computerized epicardial mapping of the right atrial (RA) free wall and the left atrial (LA) posterior wall using 224 bipolar electrodes at 3-mm spatial resolution.
C
Comparator
Intra-patient comparison between right atrial (RA) free wall and left atrial (LA) posterior wall.
O
Outcome
Activation patterns, activation cycle length, and maximum dominant frequency.surrogate

Main Result

Absolute Event Rate: 179% vs 196%

p-value: p=0.004

Epicardial mapping during permanent AF in patients with organic heart disease demonstrates shorter activation cycle lengths and higher dominant frequencies in the left atrial posterior wall compared to the right atrial free wall.

Cite This Study

Wu et al. (2002) conducted an observational in Permanent atrial fibrillation and organic heart disease (n=6). Left atrial (LA) posterior wall mapping vs. Right atrial (RA) free wall mapping was evaluated on Mean activation cycle length (msec) (p=0.004). Simultaneous biatrial mapping during permanent AF showed a shorter mean activation cycle length in the left atrial posterior wall than the right atrial free wall (179 vs 196 msec; P=0.004).

synapsesocial.com/papers/6a0f4fb1853d174eb2ed0f90https://doi.org/10.1046/j.1540-8167.2002.00571.x

Topics

Atrial fibrillationPersistent AF managementAF ablation outcomesAnticoagulation in AF
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Organized patterns of excitation during persistent atrial fibrillation in humans relate to tissue structure and activation rate2024
  2. 2Simultaneous Biatrial High-Density (510–512 Electrodes) Epicardial Mapping of Persistent and Long-Standing Persistent Atrial Fibrillation in Patients2015 · 159 citations
  3. 3Noninvasive Mapping of Human Atrial Fibrillation2008 · 71 citations
  4. 4Single Chamber Atrial Fibrillation Involving Only the Left Atrium:2003 · 10 citations
  5. 5Epicardial right atrial free wall mapping in chronic atrial fibrillation: Documentation of repetitive activation with a focal spread--a hitherto unrecognised phenomenon in man1997 · 99 citations