Simultaneous Biatrial High-Density (510–512 Electrodes) Epicardial Mapping of Persistent and Long-Standing Persistent Atrial Fibrillation in Patients
Key result
High-density epicardial mapping reveals persistent AF is maintained by multiple foci without actual reentry.
- n=12
Why the study?
What are the mechanisms (focal vs reentrant drivers) maintaining persistent and long-standing persistent atrial fibrillation?
Population
12 patients with persistent and long-standing persistent atrial fibrillation undergoing open heart surgery.
Design
Case_series
Authors
Discussion
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Implication
Supports focal over reentrant mechanisms in persistent AF; hypothesis-generating and should not change clinical practice.
Study Design
Type
Observational (n=12)
Structured PICO
What are the mechanisms (focal vs reentrant drivers) maintaining persistent and long-standing persistent atrial fibrillation?
P
Population
12 patients with persistent and long-standing persistent (LSP) atrial fibrillation (1 month to 9 years duration) undergoing open heart surgery.
I
Intervention
High-density, simultaneous, biatrial, epicardial mapping (510-512 electrodes) for 1 to 5 minutes.
O
Outcome
Identification of drivers (focal or reentrant) and characterization of associated atrial activation.surrogate
High-density epicardial mapping reveals that persistent and long-standing persistent AF is maintained by focal drivers and breakthrough sites rather than reentry.
Cite This Study
Lee et al. (2015) conducted an observational in Persistent and long-standing persistent atrial fibrillation (n=12). High-density simultaneous biatrial epicardial mapping was evaluated on Presence of focal or reentrant drivers and characterization of atrial activation. High-density biatrial epicardial mapping in 12 patients showed persistent AF is maintained by wave fronts from multiple foci and breakthrough sites, with no actual reentry demonstrated.