Key result
Healthy females exhibit ~19% greater global longitudinal strain magnitude than males on CMR.
Cross-Sectional (n=88)
Single-blind
No
Absolute Event Rate: -21.91% vs -18.48%
p-value: p=<0.001
Feature-tracking CMR at 3.0 T is feasible and demonstrates that healthy females have higher global longitudinal strain than males, with global strain measurements showing better reproducibility than segmental strain.
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Sex-specific GLS reference ranges may be needed for feature-tracking CMR; Level 4 data leaves open impact on clinical thresholds.
Mangion et al. (2019) conducted a cross-sectional in Healthy volunteers (n=88). Feature-tracking cardiac magnetic resonance imaging at 3.0 T vs. Male vs Female was evaluated on Global longitudinal strain (p=<0.001). Healthy female volunteers demonstrated higher magnitudes of global longitudinal strain compared to male counterparts (-21.91% vs -18.48%, p<0.001) using feature-tracking CMR at 3.0 T.
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