Key result
In a simulated 2-D tissue model, Na+ channel blockade decreased the vulnerable window of reentry, whereas K+ channel blockade increased it due to opposing effects on dynamical wave instability.
Why the study?
Does Na+ and K+ channel blockade affect vulnerability to and termination of fibrillation in simulated normal cardiac tissue?
Population
Computer simulation of a two-dimensional structurally normal tissue model with phase I of the Luo-Rudy…
Comparison
Na+ and K+ channel blockade vs Unblocked state (baseline simulation)
Design
Preclinical
Authors
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Computational modeling demonstrates that Na+ and K+ channel blockade have opposing effects on the vulnerable window of reentry and dynamical wave instability during fibrillation.
Does Na+ and K+ channel blockade affect vulnerability to and termination of fibrillation in simulated normal cardiac tissue?
Computational modeling demonstrates that Na+ and K+ channel blockade have opposing effects on the vulnerable window of reentry and dynamical wave instability during fibrillation.
Qu et al. (2005) studied Fibrillation. Na+ and K+ channel blockade was evaluated on Vulnerability to and termination of reentry in simulated multiple-wavelet and mother rotor fibrillation. In a simulated 2-D tissue model, Na+ channel blockade decreased the vulnerable window of reentry, whereas K+ channel blockade increased it due to opposing effects on dynamical wave instability.
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