Key result
Pure Na+-current inhibition terminated all atrial fibrillation at 65% block in a mathematical model by enlarging the center of rotation and reducing secondary wavelets.
Why the study?
Does pure sodium channel blockade terminate atrial fibrillation in mathematical models and isolated sheep hearts?
Does pure sodium channel blockade terminate atrial fibrillation in mathematical models and isolated sheep hearts?
Pure sodium channel inhibition terminates atrial fibrillation by enlarging the center of rotation, decreasing anchoring, and reducing secondary wavelets, providing mechanistic insight into class I antiarrhythmic drugs.
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May guide class I antiarrhythmic development; extends computational AF models but leaves clinical translation open.
Kneller et al. (2005) studied Atrial fibrillation. Pure Na+-current (I(Na)) inhibition vs. Control conditions was evaluated on Atrial fibrillation termination and activation changes. Pure Na+-current inhibition terminated all atrial fibrillation at 65% block in a mathematical model by enlarging the center of rotation and reducing secondary wavelets.
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