Key result
Altered Na(+) channel properties and cellular uncoupling synergistically increased the vulnerable window for reentry in simulated cardiac tissue.
Why the study?
Do altered Na+ channel and cell coupling properties increase the vulnerable window for reentry in simulated cardiac tissue?
Do altered Na+ channel and cell coupling properties increase the vulnerable window for reentry in simulated cardiac tissue?
Altered Na+ channel properties and cellular uncoupling synergistically increase vulnerability to reentrant arrhythmias in simulated cardiac tissue.
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Should not yet alter clinical arrhythmia management; extends simulation models of reentry vulnerability but leaves translation open.
Qu et al. (2004) studied reentrant arrhythmias. Altered Na(+) channel and cell coupling properties vs. Normal properties was evaluated on vulnerable window (VW) for reentry. Altered Na(+) channel properties and cellular uncoupling synergistically increased the vulnerable window for reentry in simulated cardiac tissue.
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