Characteristics of the Temporal and Spatial Excitable Gap in Anisotropic Reentrant Circuits Causing Sustained Ventricular Tachycardia
Key result
Mapping of reentrant circuits in canine infarct models revealed both temporal and spatial excitable gaps with fully and partially excitable components that vary across different parts of the circuit.
Population
Canine hearts with myocardial infarction produced by ligation of the left anterior descending coronary artery
Design
Preclinical
Authors
Discussion
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Implication
Hypothesis-generating for VT ablation targeting; leaves open translation from canine models to patients.
Structured PICO
P
Population
Canine hearts with myocardial infarction produced by ligation of the left anterior descending coronary artery (4 days post-MI)
I
Intervention
Programmed stimulation to induce sustained ventricular tachycardia and premature impulses to map conduction characteristics
O
Outcome
Temporal and spatial properties of the excitable gap in reentrant circuitssurrogate
Nonuniform anisotropic reentrant circuits in post-MI canine hearts exhibit both temporal and spatial excitable gaps with varying degrees of excitability across the circuit.
Cite This Study
Peters et al. (1998) studied Sustained ventricular tachycardia. Programmed stimulation and epicardial mapping was evaluated on Temporal and spatial properties of the excitable gap in reentrant circuits. Mapping of reentrant circuits in canine infarct models revealed both temporal and spatial excitable gaps with fully and partially excitable components that vary across different parts of the circuit.