Key result
Pacing tachycardia in dogs markedly impaired determinants of left ventricular diastolic suction, including inability to contract below equilibrium volume, reduced twist, and altered titin ratios.
Population
open-chest dogs previously subjected to 2 weeks of pacing tachycardia (PT) and controls
Comparison
2 weeks of pacing tachycardia (PT) vs controls
Design
Preclinical
Follow-up
2 weeks
Authors
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Tachycardia may impair LV diastolic suction; leaves open titin-targeted therapies for human diastolic dysfunction.
In a canine model of pacing tachycardia, determinants of diastolic suction at the LV level are markedly impaired, accompanied by an altered transmural titin isoform gradient.
Bell et al. (2000) studied Pacing tachycardia-induced heart failure. Pacing tachycardia vs. Controls was evaluated on Determinants of diastolic suction (contraction below equilibrium volume, twist, and titin isoform ratios). Pacing tachycardia in dogs markedly impaired determinants of left ventricular diastolic suction, including inability to contract below equilibrium volume, reduced twist, and altered titin ratios.
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