Key result
Fixed curve delivery sheaths linked to ~65% fewer His bundle pacing complications versus deflectable systems.
Why the study?
Existing evidence on the feasibility, safety, and clinical outcomes of permanent His bundle pacing was limited to single-center, short-term studies.
Does permanent His bundle pacing using a fixed curve sheath improve long-term electrical performance and reduce complications compared to a deflectable curve delivery system in patients with pacemaker indications?
Cohort (n=844)
Yes
Does permanent His bundle pacing using a fixed curve sheath improve long-term electrical performance and reduce complications compared to a deflectable curve delivery system in patients with pacemaker indications?
Absolute Event Rate: 4.2% vs 11.9%
p-value: p=< .001
Permanent His bundle pacing demonstrates long-term safety and stable electrical performance, with fixed curve delivery sheaths providing superior outcomes compared to deflectable systems.
No takes yet. Share an insight, caveat, or question.
Fixed-curve sheaths may reduce HBP complications; hypothesis-generating and requires randomized confirmation.
Zanon et al. (2019) conducted a cohort in Pacemaker indications (AV block, sinus node disease, bradycardia with atrial fibrillation, need for CRT) (n=844). Permanent His bundle pacing (fixed curve sheath) vs. Deflectable curve delivery system was evaluated on Freedom from pacing related complications (p=< .001). Permanent His bundle pacing using a fixed curve delivery sheath significantly reduced complications compared to a deflectable curve system (4.2% vs 11.9%, P<0.001) over a median 3-year follow-up.
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