Key result
Prophylactic amiodarone suggested reduced all-cause mortality in post-MI patients with ejection fraction <30%, arrhythmias, high heart rate, and beta-blocker use.
Why the study?
Does prophylactic amiodarone reduce all-cause mortality in specific subgroups of post acute myocardial infarction patients?
Population
1486 post acute myocardial infarction patients enrolled in the European Myocardial Infarct Amiodarone Trial
Design
Cohort
Authors
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Hypothesis-generating for targeted use in high-risk post-MI subgroups; leaves open confirmation by randomized trials.
Cohort (n=1,486)
Yes
Does prophylactic amiodarone reduce all-cause mortality in specific subgroups of post acute myocardial infarction patients?
Prophylactic amiodarone may reduce mortality in post-MI patients with LVEF <30%, high heart rate, and beta-blocker use, but may be harmful in those with LVEF 30-40% without these features.
Michiel J. Janse (1998) conducted a cohort in Post acute myocardial infarction (n=1,486). Amiodarone was evaluated on All-cause mortality. Prophylactic amiodarone suggested reduced all-cause mortality in post-MI patients with ejection fraction <30%, arrhythmias, high heart rate, and beta-blocker use.
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