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March 24, 2023Open Access

Heart failure, female sex and atrial fibrillation are the main drivers of human atrial cardiomyopathy: results from the CATCH ME consortium

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Why the study?

The contribution of various etiological factors and atrial fibrillation to the development of differential atrial cardiomyopathy phenotypes had not been robustly quantified.

Population

European cohort undergoing cardiac surgery with LA (n=95) and RA (n=76) appendage samples

Comparison

Histological features compared across clinical characteristics including AF, HF, sex, and age

Design

Cohort study

Authors

JWJoris WintersAIAaron IsaacsSZStef Zeemering

Discussion

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Overview

Should not yet change practice in atrial fibrillation; leaves open sex-stratified phenotyping trials in persistent AF and heart failure.

Structured PICO

P
Population
Patients undergoing cardiac surgery from a European cohort providing left (n=95) and right (n=76) atrial appendage samples.
O
Outcome
Association between histological features of atrial cardiomyopathy (fibrotic remodeling, cardiomyocyte hypertrophy, capillary density) and clinical phenotypes (atrial fibrillation, heart failure, sex, age).surrogate

Histological phenotypes of atrial cardiomyopathy vary significantly by patient characteristics, with fibrotic remodeling driven by female sex, persistent atrial fibrillation, and heart failure, whereas cardiomyocyte hypertrophy is more common in men.

Cite This Study

Winters et al. (2023) studied this question.

synapsesocial.com/papers/6a0f8d8c01be78fe815fd2bahttps://doi.org/10.1101/2023.03.23.23287667
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Heart Failure, Female Sex, and Atrial Fibrillation Are the Main Drivers of Human Atrial Cardiomyopathy: Results From the CATCH ME Consortium2023 · 34 citations
  2. 2Histological evaluation of clinically defined atrial cardiomyopathy stages and their association with atrial fibrillation burden under continuous monitoring for a 2.5-year follow-up2026
  3. 3Atrial cardiomyopathy: markers and outcomes2025 · 24 citations
  4. 4Clinical phenotypes of severe atrial cardiomyopathy and their outcome: A cluster analysis2025 · 1 citations
  5. 5Morphological features of the myocardium of the atrial appendages in patients with different forms of atrial fibrillation2017 · 1 citations