Key result
Antidepressant use linked to ~40% higher hypertension prevalence at age 29, unlike high depressive symptoms.
Why the study?
Does antidepressant use or high depressive symptoms increase the prevalence of hypertension in young adults?
Cohort (n=11,183)
Does antidepressant use or high depressive symptoms increase the prevalence of hypertension in young adults?
Effect estimate: PR 1.4 (95% CI 1.2-1.7)
Antidepressant use, but not depressive symptoms, is associated with an increased prevalence of hypertension in young adulthood, highlighting a potential cardiovascular side effect of these medications.
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May warrant BP monitoring during antidepressant use in young adults; leaves open causality versus confounding by indication.
Crookes et al. (2018) conducted a cohort in Hypertension (n=11,183). Antidepressant use vs. No antidepressant use was evaluated on Hypertension at age 29 (SBP ≥140 mm Hg, DBP ≥90 mm Hg, or anti-hypertensive medication use) (PR 1.4, 95% CI 1.2-1.7). Antidepressant use at age 29 was associated with an increased prevalence of hypertension (PR 1.4; 95% CI 1.2-1.7), whereas high depressive symptoms were not.
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