Key result
Targeting cardiomyocyte fate plasticity via reprogramming and proliferation shows promise for cardiac regeneration.
Why the study?
Existing pharmacological and surgical treatments improve heart function but cannot replenish the massive loss of beating cardiomyocytes after cardiac injury.
Design
Review
Authors
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Should not yet change heart failure practice; hypothesis-generating for cardiomyocyte plasticity targeting in regeneration.
Altering cardiomyocyte fate plasticity represents a promising theoretical strategy for cardiac regeneration and repairing the damaged heart to prevent heart failure.
Gong et al. (2021) conducted a review in Myocardial infarction and heart failure. Targeting cardiomyocyte fate plasticity was evaluated. Targeting cardiomyocyte fate plasticity through reprogramming non-cardiomyocytes, differentiating pluripotent stem cells, and promoting pre-existing cardiomyocyte proliferation is a promising strategy for cardiac regeneration.
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