Key result
Increasing heart rate in a thoracic aortic aneurysm model raises maximum pressure by ~50%.
Why the study?
The study was conducted to evaluate the effect of physical activity in terms of heart rate on thoracic aortic aneurysm growth.
Does an increase in heart rate affect blood flow hemodynamics in a patient with a thoracic aortic aneurysm?
Does an increase in heart rate affect blood flow hemodynamics in a patient with a thoracic aortic aneurysm?
Numerical simulations suggest that increased heart rate in a thoracic aortic aneurysm leads to undesirable hemodynamic conditions, such as increased maximum wall shear stress and pressure, which may promote aneurysm progression and rupture.
Answers are grounded in this paper and cite their sources.
Elevated heart rate may worsen wall stress in thoracic aortic aneurysms; leaves open whether rate control alters progression.
In this study, the effect of patient’s physical activity in terms of the heart rate on the growth of the thoracic aortic aneurysm (TAA) is studied. Using medical images of the patient, a patient-specific geometry model is constructed. Then the hemodynamic parameters of the blood flow are numerically analyzed for different heart rate conditions. The simulation results show that the maximum wall shear stress, the maximum velocity, and the maximum pressure during a cardiac cycle increase by 19.1, 12.7, and 50%, respectively, as the heart rate increases from 60 to 174 beats per minute. Results also indicate that an increase in the heart rate leads to reduction of the time-averaged wall shear stress and simultaneously to an increase in the wall shear stress oscillations. According to the literature, these hemodynamic conditions are undesirable and can increase the likelihood of aneurysm development and aortic rupture.
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Faraji et al. (2024) studied Thoracic aortic aneurysm (n=1). Increased heart rate (physical activity) vs. Baseline heart rate (60 bpm) was evaluated on Hemodynamic parameters (wall shear stress, velocity, pressure). Increasing heart rate from 60 to 174 bpm in a patient-specific thoracic aortic aneurysm model increased maximum wall shear stress by 19.1%, maximum velocity by 12.7%, and maximum pressure by 50%.
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