Key result
Inflammation offers a viable therapeutic target in HFpEF despite most prior trials targeting HFrEF.
Why the study?
Unlike heart failure with reduced ejection fraction, few evidence-based treatment strategies are available for HFpEF, highlighting an unmet need for new strategies targeting pathophysiology such as inflammation.
Do therapeutic strategies targeting inflammation improve clinical outcomes in patients with heart failure with preserved ejection fraction (HFpEF)?
Do therapeutic strategies targeting inflammation improve clinical outcomes in patients with heart failure with preserved ejection fraction (HFpEF)?
This review highlights the pathophysiological role of inflammation in HFpEF and explores its potential as a therapeutic target to address the significant unmet need for evidence-based treatments.
Does not support anti-inflammatory therapy in HFpEF; leaves open dedicated outcome trials in preserved EF.
Heart failure with preserved ejection fraction (HFpEF) accounts for around half of all cases of heart failure and may become the dominant type of heart failure in the near future. Unlike HF with reduced ejection fraction there are few evidence-based treatment strategies available. There is a significant unmet need for new strategies to improve clinical outcomes in HFpEF patients. Inflammation is widely thought to play a key role in HFpEF pathophysiology and may represent a viable treatment target. In this review focusing predominantly on clinical studies, we will summarise the role of inflammation in HFpEF and discuss potential therapeutic strategies targeting inflammation.
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Peh et al. (2023) conducted a review in Heart failure with preserved ejection fraction (HFpEF). Anti-inflammatory therapies was evaluated. Inflammation is highly prevalent in heart failure with preserved ejection fraction and represents a viable therapeutic target, though most clinical trials of anti-inflammatory therapies to date have been conducted in patients with reduced ejection fraction.
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