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July 28, 2015European Heart JournalOpen Access

Wild-type transthyretin amyloidosis as a cause of heart failure with preserved ejection fraction

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Population

Patients with heart failure with preserved ejection fraction (HFpEF)

Design

Other

Authors

EGEsther González-LópezHeart Failure & TransplantMGMaría Gallego‐DelgadoHeart Failure / CardiomyopathyGGGonzalo Guzzo-MerelloHospital Universitario Puerta de Hierro Majadahonda

Discussion

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Implication

May support ATTRwt screening in HFpEF; leaves open whether diagnosis improves outcomes.

Structured PICO

P
Population
Patients with heart failure with preserved ejection fraction (HFpEF)

Wild-type transthyretin amyloidosis is an underdiagnosed condition that accounts for a significant proportion (13%) of HFpEF cases.

Cite This Study

González-López et al. (2015) studied this question.

synapsesocial.com/papers/69aea5047defb997d5abdda7https://doi.org/10.1093/eurheartj/ehv338

Topics

HFrEF treatmentHeart failureEchocardiographyHFpEF management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical development of an antisense therapy for the treatment of transthyretin-associated polyneuropathy2012 · 136 citations
  2. 2How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology2007 · 2,689 citations
  3. 3The Clinical Significance of Senile Cardiac Amyloidosis: A Prospective Clinico-Pathological Study1977 · 110 citations
  4. 4Doxycycline plus tauroursodeoxycholic acid for transthyretin amyloidosis: a phase II study2012 · 232 citations
  5. 5Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2‐macroglobulin and tau : A population‐based autopsy study2008 · 595 citations