March 9, 2004Hypertension
Relations of Serum Aldosterone to Cardiac Structure
Key result
Serum aldosterone was positively associated with increased left ventricular wall thickness and relative wall thickness, and decreased internal dimensions in women (P<0.05) but not in men.
Why the study?
Is serum aldosterone associated with echocardiographic left ventricular measurements in individuals free of myocardial infarction and heart failure?
Population
2820 Framingham Study subjects free of myocardial infarction and overt heart failure
Design
Cohort
Authors
Discussion
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Implication
Sex-specific concentric remodeling link in women; hypothesis-generating and should not yet change practice.
Study Design
Type
Observational (n=2,820)
Structured PICO
Is serum aldosterone associated with echocardiographic left ventricular measurements in individuals free of myocardial infarction and heart failure?
P
Population
2820 Framingham Study subjects (mean age 57 years, 58% women, 88% white) free of myocardial infarction and overt heart failure
I
Intervention
Serum aldosterone
O
Outcome
Echocardiographic left ventricular measurements (left ventricular wall thickness, relative wall thickness, and left ventricular diastolic dimensions)surrogate
Main Result
p-value: p=<0.05
Higher serum aldosterone levels are associated with echocardiographic signs of concentric left ventricular remodeling in women, but not men, without overt heart failure or prior myocardial infarction.
Cite This Study
Vasan et al. (2004) conducted an observational in Free of myocardial infarction and overt heart failure (n=2,820). Serum aldosterone was evaluated on Echocardiographic left ventricular measurements (p=<0.05). Serum aldosterone was positively associated with increased left ventricular wall thickness and relative wall thickness, and decreased internal dimensions in women (P<0.05) but not in men.