Increased serum aldosterone concentration was independently associated with concentric left ventricular hypertrophy in patients with essential hypertension (OR 1.21; 95% CI 1.11-1.33; P<0.001).
Cross-Sectional (n=213)
Is serum aldosterone concentration associated with left ventricular structure and diastolic function in patients with essential hypertension?
Higher serum aldosterone concentration, independent of blood pressure, is associated with concentric left ventricular hypertrophy and worse diastolic function in patients with essential hypertension.
Odds Ratio: 1.21 (95% CI 1.11–1.33)
p-value: p=<0.001
Aldosterone has hypertrophic and profibrotic effects on the heart. This study aims to determine the relationship between serum aldosterone concentration (SAC) and aldosterone-to-renin ratio (ARR) with left ventricular (LV) geometry and diastolic function in essential hypertension (EH). We investigated 213 EH patients (50.3 ± 12.6 years; 57.7% male). SAC, ARR measurements, and echocardiographic analysis were performed for participants. Overall, stepwise multiple regression analysis showed significant associations between SAC and interventricular septum, LV posterior wall thickness, LV amass, LV mass index, e' velocity, a' velocity, and E/e' ratio after adjustment of potentially confounding covariates. When patients were divided into three SAC tertiles, multivariate-adjusted analysis of covariance (ANCOVA) demonstrated a significant increase in LV mass (P ˂ 0.001), LV mass index (P ˂ 0.001), relative wall thickness (P = 0.003), interventricular septum (P = 0.001), LV posterior wall thickness (P = 0.001) and E/e' ratio (P ˂ 0.001), but a decrease in e' velocity (P = 0.002) from the first to third tertile of SAC. In logistic regression analysis, increased SAC was independently associated with concentric LV hypertrophy OR: 1.21, 95% CI: 1.11-1.33, P ˂ 0.001. No significant associations were found between ARR and echocardiographic parameters of LV structure or diastolic function. In conclusion, SAC, but not ARR, is independently associated with echocardiographic indices of LV structure and diastolic function and is also related to concentric LV hypertrophy. Our findings suggest that aldosterone's pro-hypertrophic and myocardial fibrosis effects contribute to alterations in LV structure and diastolic function in EH beyond blood pressure.
Al‐Hashedi et al. (Fri,) conducted a cross-sectional in Essential hypertension (n=213). Serum aldosterone concentration vs. Lower serum aldosterone concentration was evaluated on Concentric left ventricular hypertrophy (OR 1.21, 95% CI 1.11-1.33, p=<0.001). Increased serum aldosterone concentration was independently associated with concentric left ventricular hypertrophy in patients with essential hypertension (OR 1.21; 95% CI 1.11-1.33; P<0.001).