Why the study?
Heparins can interfere with lupus anticoagulant testing, particularly when detection assays lack a heparin neutralizer.
Does polybrene neutralize the effects of unfractionated heparin on aPTT-based lupus anticoagulant testing in patients receiving UFH?
Population
14 patients receiving UFH therapy
Comparison
aPTT-based LA testing before vs after polybrene treatment
Authors
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May allow accurate aPTT-LA testing on UFH; leaves open validation in larger prospective studies.
Does polybrene neutralize the effects of unfractionated heparin on aPTT-based lupus anticoagulant testing in patients receiving UFH?
Polybrene can effectively neutralize unfractionated heparin in plasma samples, allowing for accurate aPTT-based lupus anticoagulant testing.
Kongkan et al. (2022) studied this question.
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