Why the study?
Does the Polybrene neutralization test provide a rapid and accurate means of monitoring blood heparin levels in patients receiving heparin anticoagulation?
Population
Patients receiving heparin anticoagulation, including those receiving concurrent Warfarin anticoagulants
Design
Other
Authors
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May support heparin monitoring at high doses or with Warfarin; leaves open prospective validation before clinical adoption.
Does the Polybrene neutralization test provide a rapid and accurate means of monitoring blood heparin levels in patients receiving heparin anticoagulation?
Polybrene neutralization provides a rapid, simple, and accurate method for monitoring heparin levels, even at high concentrations or with concurrent Warfarin use, and aids in quantifying protamine dosage for neutralization.
Grann et al. (1972) studied this question.
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