Key result
Polybrene neutralizes high-dose heparin without altering ETP whereas protamine yields limited reversal.
Why the study?
The anticoagulating and heparin-neutralizing properties of protamine and polybrene on plasma coagulability measured by endogenous thrombin potential were unclear.
Does polybrene neutralize high-dose heparin more effectively than protamine in vitro?
Population
Plasma samples
Comparison
Polybrene vs protamine for heparin neutralization
Design
In vitro experimental study
Authors
Loading...
May support polybrene over protamine for high-dose heparin reversal in vitro; leaves open translation to in vivo or clinical use.
Does polybrene neutralize high-dose heparin more effectively than protamine in vitro?
In vitro experiments suggest polybrene is superior to protamine for neutralizing high doses of heparin, indicating current in vivo practices may need reconsideration.
Rotteveel et al. (2009) studied Heparin-induced hypocoagulability. Polybrene (hexadimethrine bromide) vs. Protamine was evaluated on Endogenous thrombin potential (ETP). Polybrene neutralized high doses of heparin without influencing ETP parameters, whereas protamine reversed heparin-induced hypocoagulability to a very limited extent.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: