Why the study?
Do protamine and hexadimethrine effectively neutralize the effects of heparin in animal models?
Population
Rabbits with no extracorporeal circulation; normal animals and animals in peptone shock or experimental…
Design
Review
Authors
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Supports hexadimethrine development for heparin reversal; leaves open clinical translation from animal data.
Do protamine and hexadimethrine effectively neutralize the effects of heparin in animal models?
Protamine and hexadimethrine are effective agents for neutralizing heparin and restoring normal coagulation times in experimental models.
Richard A. Goldman (1962) studied this question.
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