Key result
Hexadimethrine reversed heparin-induced anticoagulation as well as protamine, whereas methylene blue and vancomycin did not neutralize heparin in vitro.
Why the study?
Can methylene blue, hexadimethrine, or vancomycin reverse heparin-induced anticoagulation in blood from cardiopulmonary bypass circuits?
Population
Blood obtained from extracorporeal circuits after cardiopulmonary bypass (n=18)
Comparison
Methylene blue, hexadimethrine, or vancomycin… vs Protamine and heparinase-ACT
Design
Preclinical
Authors
Loading...
Hexadimethrine reversed heparin in vitro like protamine; leaves open clinical utility and safety in cardiopulmonary bypass.
Can methylene blue, hexadimethrine, or vancomycin reverse heparin-induced anticoagulation in blood from cardiopulmonary bypass circuits?
Hexadimethrine, but not methylene blue or vancomycin, effectively reverses heparin-induced anticoagulation in vitro, suggesting potential as an alternative to protamine.
Kikura et al. (1996) studied Heparin reversal after cardiopulmonary bypass (n=18). Methylene blue, hexadimethrine, or vancomycin vs. Protamine (13.5-270.3 µg/mL) and heparinase-ACT was evaluated on Activated clotting times (ACTs) measured with kaolin. Hexadimethrine reversed heparin-induced anticoagulation as well as protamine, whereas methylene blue and vancomycin did not neutralize heparin in vitro.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: