Key result
Heparsorb effectively neutralizes heparin in plasma to restore baseline coagulation test results.
Why the study?
Does incubation with an anion-exchange resin (Heparsorb) allow accurate coagulation testing in heparinized blood?
Population
Plasma samples from normal individuals, patients receiving coumadin therapy, 9 patients receiving heparin…
Comparison
Incubation of citrated plasma containing heparin… vs Plasma before heparin administration
Design
Other
Authors
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Heparsorb may enable reliable coagulation testing in heparinized samples; leaves open prospective validation before routine adoption.
Does incubation with an anion-exchange resin (Heparsorb) allow accurate coagulation testing in heparinized blood?
The use of an anion-exchange resin (Heparsorb) effectively neutralizes heparin in plasma samples, allowing for accurate routine coagulation testing in patients receiving heparin therapy.
Cowan et al. (1981) studied Patients receiving heparin therapy (n=16). Heparin neutralizer (Heparsorb) vs. Pre-heparin administration samples was evaluated on Coagulation test results (aPTT, PT, TT) and fibrinogen/fibrin degradation products. Treatment of heparinized plasma with Heparsorb effectively neutralized heparin, yielding coagulation test results virtually identical to pre-heparin baseline values.
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