Key result
Endotoxin administration in mice induces the production of a humoral factor by exudate cells that markedly suppresses adipose tissue lipoprotein lipase activity.
Population
C3H/HeN (endotoxin-sensitive) and C3H/HeJ (endotoxin-resistant) mice
Comparison
Endotoxin administration and conditioned medium… vs C3H/HeJ mice (endotoxin-resistant) and baseline
Design
Preclinical
Follow-up
up to 16 hours
Authors
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May explain sepsis-associated hyperlipidemia mechanisms; leaves open translation to human pathophysiology.
Demonstrates that endotoxin-induced hyperlipidemia is mediated by a humoral factor from exudate cells that suppresses adipose tissue lipoprotein lipase.
Kawakami et al. (1981) studied Endotoxin-induced hyperlipidemia. Endotoxin administration vs. C3H/HeJ (endotoxin-resistant) mice was evaluated on Lipoprotein lipase (LPL) activity in adipose tissue. Endotoxin administration in mice induces the production of a humoral factor by exudate cells that markedly suppresses adipose tissue lipoprotein lipase activity.
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