Key result
Conditioned medium from endotoxin-treated mouse peritoneal exudate cells suppressed lipoprotein lipase activity in differentiating 3T3-L1 mouse preadipocytes by greater than 90%.
Endotoxin promotes the release of a mediator from exudate cells that suppresses lipoprotein lipase activity in preadipocytes, providing a potential mechanism for lipid metabolism alterations during infection.
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May inform mechanisms of infection-related dyslipidemia in models; leaves open mediator identity and human relevance.
Kawakami et al. (1982) studied Hypertriglyceridemia/infection/shock (in vitro model). Conditioned medium from endotoxin-treated exudate cells vs. Conditioned medium from untreated exudate cells or fresh medium was evaluated on Lipoprotein lipase activity. Conditioned medium from endotoxin-treated mouse peritoneal exudate cells suppressed lipoprotein lipase activity in differentiating 3T3-L1 mouse preadipocytes by greater than 90%.
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