December 1, 1986Biochemical JournalOpen Access

Regulation of lipoprotein lipase synthesis in 3T3-L1 adipocytes by cachectin Further proof for identity with tumour necrosis factor

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Population

3T3-L1 adipocytes

Design

Preclinical

Authors

SPS. Russ PriceEast Carolina University TOThomas OlivecronaGeneral / Preventive / Lipids PPP H PekalaBoston University

Discussion

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Implication

Suggests TNF/cachectin links inflammation to lipid dysregulation; leaves open clinical translation in cachexia.

Structured PICO

Population

3T3-L1 adipocytes

Intervention

Cachectin (crude conditioned medium or highly purified preparation)

Outcome

Lipoprotein lipase synthesis (incorporation of [35S]methionine into immunoprecipitable lipoprotein lipase)surrogate

This preclinical study demonstrates that cachectin suppresses lipoprotein lipase synthesis in adipocytes, providing further evidence that cachectin and tumor necrosis factor are functionally identical.

Cite This Study

Price et al. (1986) studied this question.

synapsesocial.com/papers/6a702fd55d37378ac1dd4174 https://doi.org/10.1042/bj2400601

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Regulation of lipoprotein lipase synthesis in 3T3-L1 adipocytes by cachectin Further proof for identity with tumour necrosis factor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regulation of lipoprotein lipase synthesis in 3T3-L1 adipocytes by cachectin Further proof for identity with tumour necrosis factor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider