Key result
Plasma from colon-26 clone 20-inoculated mice induced lipid depletion in 3T3-L1 adipocytes by stimulating lipolysis and inhibiting lipogenesis via SREBP-1, distinct from IL-6 or TNF-alpha.
Population
Mouse cachexia model (colon-26-inoculated mice) and differentiated 3T3-L1 adipocytes
Comparison
Clone 20-derived cachexigenic plasma vs Clone 5-derived noncachexigenic plasma or…
Design
Preclinical
Authors
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May identify a novel cachexia mediator; leaves open human relevance and therapeutic targeting.
The study identifies a lipid-depleting factor in a cancer cachexia model that promotes lipolysis and inhibits lipogenesis via SREBP-1, distinct from known cytokines like IL-6 and TNF-alpha.
Inadera et al. (2002) studied Cancer cachexia. Colon-26 clone 20-derived cachexigenic plasma vs. Clone 5-derived noncachexigenic plasma was evaluated on Lipid-depleting activity (TG content reduction, lipolysis, and lipogenesis). Plasma from colon-26 clone 20-inoculated mice induced lipid depletion in 3T3-L1 adipocytes by stimulating lipolysis and inhibiting lipogenesis via SREBP-1, distinct from IL-6 or TNF-alpha.
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