Why the study?
Does 3D 123I-mIBG cardiac innervation mapping identify arrhythmogenic substrate and successful ablation sites better than standard voltage mapping in patients with ischemic VT?
Population
15 patients referred for ischemic ventricular tachycardia (VT) ablation
Comparison
Preprocedural cardiac 123I-meta-iodobenzylguanidi… vs Standard bipolar voltage mapping
Design
Cohort
Authors
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May extend VT substrate mapping beyond voltage criteria in ischemic cardiomyopathy; hypothesis-generating for 123I-mIBG-guided ablation.
Does 3D 123I-mIBG cardiac innervation mapping identify arrhythmogenic substrate and successful ablation sites better than standard voltage mapping in patients with ischemic VT?
123I-mIBG innervation mapping identifies larger areas of abnormal substrate than standard voltage mapping, and all successful VT ablation sites localize to these abnormally innervated regions, suggesting its potential to guide ablation.
Klein et al. (2015) studied this question.
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