August 1, 2008Circulation Cardiovascular Imaging
123 I- m IBG Scintigraphy to Predict Inducibility of Ventricular Arrhythmias on Cardiac Electrophysiology Testing
Why the study?
Do standard indices of 123I-mIBG imaging predict the inducibility of ventricular arrhythmias on cardiac electrophysiology testing in patients with left ventricular dysfunction and previous myocardial infarction?
Population
50 patients with left ventricular dysfunction and previous myocardial infarction
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Standard 123I-mIBG indices should not guide arrhythmia risk assessment in post-MI LV dysfunction; leaves open SPECT defect scoring for prospective validation.
Structured PICO
Do standard indices of 123I-mIBG imaging predict the inducibility of ventricular arrhythmias on cardiac electrophysiology testing in patients with left ventricular dysfunction and previous myocardial infarction?
P
Population
50 patients with left ventricular dysfunction and previous myocardial infarction
I
Intervention
123I-mIBG scintigraphy (15-minute and 4-hour planar and SPECT imaging) and 99mTc-tetrofosmin SPECT imaging
O
Outcome
4-hour heart:mediastinum ratio (H/M) and the 123I-mIBG/99mTc-tetrofosmin SPECT mismatch scoresurrogate
Standard indices of 123I-mIBG imaging do not predict EP test results, though SPECT defect severity showed potential predictive value requiring further validation.
Limitations
- exploratory pilot study
- requires confirmation in a larger cohort
Cite This Study
Bax et al. (2008) studied this question.