November 16, 2023Circulation JournalOpen Access

Hypokalemia, Kidney Function, and Clinical Outcomes in Heart Failure With Preserved Ejection Fraction

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Why the study?

The association of hypokalemia with kidney function and clinical outcomes in patients with HFpEF remains unclear.

Does hypokalemia increase the risk of heart failure-related events in patients with HFpEF?

Population

Patients with HFpEF

Comparison

Patients with hypokalemia vs those without hypokalemia

Follow-up

Median 1,000 days

Authors

YOYoichiro OtakiYamagata University TWTetsu WatanabeYamagata University RYRyuhei YAMAGUCHIYamagata University

Discussion

Member takes

Implication

May warrant potassium vigilance in HFpEF admissions; leaves open whether correction reduces events.

Structured PICO

Does hypokalemia increase the risk of heart failure-related events in patients with HFpEF?

Population

454 patients with heart failure with preserved ejection fraction (HFpEF, LVEF ≥50%), mean age 73.6 years, 54% men, admitted for diagnosis or treatment of acute or chronic HF exacerbation.

Intervention

Hypokalemia (serum potassium <3.5 mmol/L) at admission

Comparator

Control group (serum potassium ≥4.0 mmol/L) and mild hypokalemia (serum potassium 3.5–3.9 mmol/L)

Outcome

Heart failure-related events (composite of hospitalizations due to worsening of HF and HF-related death) at median 1,000 days follow-upcomposite

In patients with HFpEF, hypokalemia at admission is strongly associated with renal tubular damage and independently predicts an increased risk of heart failure-related events.

Limitations

Prospective observational study design cannot determine the mechanism by which hypokalemia exacerbates clinical outcomes

Cite This Study

Otaki et al. (2023) studied this question.

synapsesocial.com/papers/6a0fc8ca5725bbd5cc6016a8 https://doi.org/10.1253/circj.cj-23-0562

Topics

HFrEF treatment Heart failure HFpEF management

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Hypokalemia, Kidney Function, and Clinical Outcomes in Heart Failure With Preserved Ejection Fraction

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Hypokalemia, Kidney Function, and Clinical Outcomes in Heart Failure With Preserved Ejection Fraction

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider