Why the study?
Does heart failure induce autonomic remodeling in the left atrium and pulmonary veins that contributes to atrial fibrillation substrate?
Population
77 dogs (38 rapid ventricular-paced dogs [CHF group] and 39 control dogs)
Comparison
Electrophysiological mapping under various… vs Control dogs (n=39)
Design
Preclinical
Authors
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Autonomic remodeling may sustain AF in heart failure; leaves open whether parasympathetic blockade alters human outcomes.
Does heart failure induce autonomic remodeling in the left atrium and pulmonary veins that contributes to atrial fibrillation substrate?
In a canine model of heart failure, autonomic and electrophysiological remodeling occurs in the posterior left atrium and pulmonary veins, contributing to atrial fibrillation maintenance.
Ng et al. (2011) studied this question.
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