December 23, 2014Journal of Cardiovascular Electrophysiology
Five‐Year Outcomes of Catheter Ablation in Patients with Atrial Fibrillation and Left Ventricular Systolic Dysfunction
Why the study?
Does catheter ablation improve long-term outcomes (mortality, heart failure, stroke) in patients with atrial fibrillation and severe systolic heart failure (EF ≤35%)?
Population
2,403 patients with severe systolic heart failure, matched 1:4:4 by age and sex into three groups: AF…
Comparison
Catheter ablation (first ablation) vs No ablation and no AF
Design
Cohort
Follow-up
5 years
Authors
Discussion
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Member takes
Implication
AF ablation was associated with lower mortality in severe systolic HF; hypothesis-generating and requires randomized confirmation.
Structured PICO
Does catheter ablation improve long-term outcomes (mortality, heart failure, stroke) in patients with atrial fibrillation and severe systolic heart failure (EF ≤35%)?
P
Population
2,403 patients with severe systolic heart failure (EF ≤35%), matched 1:4:4 by age and sex into three groups: AF patients receiving their first ablation (n=267), AF patients not receiving ablation (n=1,068), and SHF patients without AF (n=1,068).
I
Intervention
Catheter ablation (first ablation)
C
Comparator
No ablation (for AF patients) and no AF (for SHF controls)
O
Outcome
AF recurrence, heart failure, stroke, death, and cardiac function at 5 yearshard clinical
Catheter ablation for AF in patients with severe systolic heart failure is associated with significantly lower 5-year mortality and HF hospitalizations compared to medical management, despite high AF recurrence rates.
Cite This Study
Bunch et al. (2014) studied this question.