What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Hypercholesterolemia and type 1 diabetes (n=88). Intervention: Abdominal aortic intima-media thickness (aIMT) measurement vs. Healthy controls. Primary outcome: aIMT and cIMT (p=<0.001).

What question did this study set out to answer?

To evaluate the feasibility of measuring abdominal aortic intima-media thickness (aIMT) in children and determine its ability to differentiate high-risk children from healthy controls relative to common carotid artery intima-media thickness (cIMT).

December 11, 2001CirculationOpen Access

Increased Aortic Intima-Media Thickness

Q: What are the key findings of this study?

Abdominal aortic intima-media thickness was significantly increased in children with hypercholesterolemia or diabetes compared with healthy controls (P<0.001).

Q: What question did this study set out to answer?

To evaluate the feasibility of measuring abdominal aortic intima-media thickness (aIMT) in children and determine its ability to differentiate high-risk children from healthy controls relative to common carotid artery intima-media thickness (cIMT).

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Key result

Abdominal aortic intima-media thickness was significantly increased in children with hypercholesterolemia or diabetes compared with healthy controls (P<0.001).

Why the study?

Does abdominal aortic intima-medial thickness (aIMT) measurement distinguish high-risk children from healthy controls better than common carotid artery intima-medial thickness (cIMT)?

Population

88 children; 16 with hypercholesterolemia, 44 with type 1 diabetes, and 28 healthy controls.

Comparison

Measurement of abdominal aortic intima-medial… vs Measurement of common carotid artery…

Design

Cross-sectional

Authors

MJMikko J. JärvisaloPreventive Cardiology LJLaura JarttiTurku City Hospital KNKirsti Näntö‐SalonenUniversity of Turku

Discussion

Member takes

Implication

Supports aIMT as feasible marker in high-risk children; leaves open superiority to cIMT and outcome validation.

Key Points

To evaluate the feasibility of measuring abdominal aortic intima-media thickness (aIMT) in children and determine its ability to differentiate high-risk children from healthy controls relative to common carotid artery intima-media thickness (cIMT).
Assessed intima-media thickness using 13 MHz high-resolution ultrasound in 88 children aged 11±2 years.
Cohorts included 16 children with hypercholesterolemia (LDL 5.1±1.2 mmol/L), 44 with type 1 diabetes (mean duration 4.4±3.1 years; LDL 2.3±0.7 mmol/L), and 28 healthy controls (LDL 2.5±0.8 mmol/L).
Both aIMT and cIMT were significantly increased in high-risk children compared with healthy controls (both P<0.001).
While aIMT and cIMT were comparable in healthy controls (P=NS), aIMT was significantly greater than cIMT in children with hypercholesterolemia and type 1 diabetes (both P<0.01).
Both vascular markers demonstrated reliable reproducibility with low between-observer (<4%) and between-subject (<5%) variation.

Study Design

Type

Cross-Sectional (n=88)

Structured PICO

Does abdominal aortic intima-medial thickness (aIMT) measurement distinguish high-risk children from healthy controls better than common carotid artery intima-medial thickness (cIMT)?

Population

88 children (aged 11+/-2 years); 16 with hypercholesterolemia, 44 with type 1 diabetes, and 28 healthy controls.

Intervention

Measurement of abdominal aortic intima-medial thickness (aIMT) using high-resolution (13 MHz) ultrasound

Comparator

Measurement of common carotid artery intima-medial thickness (cIMT)

Outcome

Value in distinguishing high-risk children from healthy controls (aIMT vs cIMT)surrogate

Main Result

p-value: p=<0.001

Abdominal aortic intima-medial thickness (aIMT) is a feasible and potentially superior noninvasive marker of preclinical atherosclerosis in high-risk children compared to carotid IMT.

Cite This Study

Järvisalo et al. (2001) conducted a cross-sectional in Hypercholesterolemia and type 1 diabetes (n=88). Abdominal aortic intima-media thickness (aIMT) measurement vs. Healthy controls was evaluated on aIMT and cIMT (p=<0.001). Abdominal aortic intima-media thickness was significantly increased in children with hypercholesterolemia or diabetes compared with healthy controls (P<0.001).

synapsesocial.com/papers/6a0fd21f2badbc352afec5fb https://doi.org/10.1161/hc4901.100522

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Increased Aortic Intima-Media Thickness

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Increased Aortic Intima-Media Thickness

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

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Also Consider