What question did this study set out to answer?

To evaluate the prevalence and underlying mechanisms of cerebral ischemic events among patients diagnosed with mitral valve prolapse.

July 1, 1982StrokeOpen Access

Cerebral ischemic events in patients with mitral valve prolapse.

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Why the study?

Is mitral valve prolapse associated with an increased prevalence of cerebral ischemic events?

Population

1,138 patients 20 years old or older referred for echocardiographic examination and found to have mitral…

Design

Cross-sectional

Authors

BSBurton A. SandokMayo Clinic in Arizona EGEnrico GiulianiGuardia Civil

Discussion

Member takes

Implication

Should not change MVP management; leaves open causal role in cerebral ischemia.

Key Points

To evaluate the prevalence and underlying mechanisms of cerebral ischemic events among patients diagnosed with mitral valve prolapse.
Evaluated 1,138 consecutive patients aged 20 years or older (mean age 48.4 years; two-thirds women) referred for echocardiographic examination and diagnosed with mitral valve prolapse between January 1975 and December 1979.
Assessed patient histories for prior focal cerebrovascular ischemic events, bacterial endocarditis, and alternative stroke etiologies.
Forty patients (3.5%) had a prior history of focal cerebrovascular ischemic events, with 26 having no identifiable mechanism other than mitral valve prolapse and 4 occurring alongside bacterial endocarditis.
Evidence indicating an embolic mechanism was present in 10 of the 26 patients with no alternative causes.
The conservative prevalence rate of cerebral infarction was four-fold higher than the rate expected in the normal population.

Structured PICO

Is mitral valve prolapse associated with an increased prevalence of cerebral ischemic events?

Population

1,138 patients 20 years old or older referred for echocardiographic examination and found to have mitral valve prolapse between January 1975 and December 1979. Average age 48.4 years, two-thirds women.

Comparator

Normal population (for prevalence comparison)

Outcome

Prevalence of prior focal cerebrovascular ischemic events (cerebral infarction)hard clinical

Mitral valve prolapse is associated with a four-fold higher prevalence of cerebral infarction compared to the normal population, suggesting a role in the pathogenesis of cerebral ischemic events.

Cite This Study

Sandok et al. (1982) studied this question.

synapsesocial.com/papers/6a0fdc7e600bce7eadfcaa49 https://doi.org/10.1161/01.str.13.4.448

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Cerebral ischemic events in patients with mitral valve prolapse.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Cerebral ischemic events in patients with mitral valve prolapse.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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