Key result
Prolapsing mitral valve was associated with recurrent transient cerebral ischemic attacks and partial nonprogressive strokes in 12 patients with an average age of 38 years.
Observational (n=12)
This case series highlights prolapsing mitral valve as a potential embolic source for transient ischemic attacks and strokes in young patients without traditional cardiovascular risk factors.
May prompt echocardiography for mitral valve prolapse in young cryptogenic stroke patients; hypothesis-generating and requires prospective validation.
Twelve patients who had no evidence of arteriosclerotic cerebral vascular disease, lacked hypertension or coagulation defect, and had not been receiving contraceptive therapy had recurrent transient cerebral ischemic attacks (TIAs) and partial nonprogressive strokes. All had prolapsing mitral valve proved by angiocardiography. The average age was 38 years, compared with 62 years in a larger series of patients with TIA associated with arteriosclerosis. We propose that the ischemic events are related to emboli emanating from the abnormal mitral valve with or without an associated paroxysmal cardiac arrhythmia.
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Barnett et al. (1976) conducted an observational in Recurrent transient cerebral ischemic attacks (TIAs) and partial nonprogressive strokes (n=12). Prolapsing mitral valve vs. Patients with TIA associated with arteriosclerosis was evaluated on Recurrent transient cerebral ischemic attacks (TIAs) and partial nonprogressive strokes. Prolapsing mitral valve was associated with recurrent transient cerebral ischemic attacks and partial nonprogressive strokes in 12 patients with an average age of 38 years.
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