Key result
Normotensive young adults with hypertensive parents had thicker, overactive left ventricles at rest, with no further LV function increase during handgrip despite hemodynamic increases (P<0.001).
Why the study?
Does a high genetic risk for hypertension alter left ventricular anatomy and function at rest and during handgrip exercise in normotensive young adults?
Population
48 normotensive young adults
Comparison
Handgrip exercise vs Rest (and comparison between HP+ and HP- groups)
Design
Case-control
Authors
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No immediate clinical implications for screening or intervention; leaves open whether changes predict incident hypertension.
Case-Control (n=48)
Does a high genetic risk for hypertension alter left ventricular anatomy and function at rest and during handgrip exercise in normotensive young adults?
p-value: p=<.001
Normotensive young adults with a high genetic risk for hypertension exhibit preclinical structural and functional left ventricular changes at rest and an impaired functional reserve during handgrip exercise.
Grandi et al. (1995) conducted a case-control in High genetic risk for hypertension (n=48). Handgrip exercise vs. Rest / Offspring of normotensive parents was evaluated on Left ventricular anatomy and function at rest and during handgrip (p=<.001). Normotensive young adults with hypertensive parents had thicker, overactive left ventricles at rest, with no further LV function increase during handgrip despite hemodynamic increases (P<0.001).
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