Why the study?
Do HDL-related biomarkers, such as cholesterol efflux capacity and HDL particle number, predict incident cardiovascular events in individuals with normal LDL and elevated CRP?
Population
314 cases of incident cardiovascular disease and age- and gender-matched controls from the JUPITER trial.
Comparison
Assessment of HDL-related biomarkers at baseline… vs Age- and gender-matched controls without…
Design
Case-control
Authors
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May aid residual risk stratification in statin-treated patients with elevated CRP; leaves open prospective validation before clinical adoption.
Do HDL-related biomarkers, such as cholesterol efflux capacity and HDL particle number, predict incident cardiovascular events in individuals with normal LDL and elevated CRP?
HDL particle number is a stronger inverse predictor of incident cardiovascular events and biomarker of residual risk than cholesterol efflux capacity, both at baseline and on potent statin therapy.
Khera et al. (2017) studied this question.
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