Key result
Experimental hypertension in dogs significantly increased the elastic stiffness of the femoral artery from 1,813 g/cm2 to 3,650 g/cm2 (p<0.005) and increased arterial water content.
Why the study?
Does experimental hypertension alter the mechanical and chemical properties of femoral arteries in dogs?
Population
20 stock mongrel dogs (over 12 kg, middle age)
Comparison
Experimental hypertension produced by wrapping… vs Contralateral femoral artery before hypertension
Design
Preclinical
Follow-up
at least 4 weeks
Authors
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Hypertension-induced femoral artery stiffening in dogs leaves open translation to human vascular disease; warrants mechanistic and clinical validation.
Does experimental hypertension alter the mechanical and chemical properties of femoral arteries in dogs?
Absolute Event Rate: 3650% vs 1813%
p-value: p=<0.005
Experimental hypertension in dogs significantly increases the elastic stiffness and water content of femoral arteries in vivo, independent of elastic nonlinearity.
Feigl et al. (1963) studied Experimental hypertension (n=20). Experimental hypertension (kidney wrapping with cellophane) vs. Normotensive state (each dog served as its own control) was evaluated on Elastic stiffness (Ep) of the femoral artery (g/cm2) (p=<0.005). Experimental hypertension in dogs significantly increased the elastic stiffness of the femoral artery from 1,813 g/cm2 to 3,650 g/cm2 (p<0.005) and increased arterial water content.
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