Key result
Insulin exhibited a more sensitive antilipolytic effect in subcutaneous compared to omental adipose tissue (half-maximal effect 1 vs 3 microU/ml, P<0.01) due to higher receptor affinity.
Why the study?
Does the antilipolytic action of insulin differ between human omental and subcutaneous adipose tissue?
Population
16 nonobese subjects who were undergoing elective abdominal surgery but were otherwise healthy
Comparison
Insulin (in vitro application) vs Comparison between omental and subcutaneous…
Design
Preclinical
Authors
Loading...
Hypothesis-generating for depot-specific insulin action in animals; leaves open translation to human diabetes care.
Observational (n=16)
Does the antilipolytic action of insulin differ between human omental and subcutaneous adipose tissue?
Absolute Event Rate: 1% vs 3%
p-value: p=<0.01
Insulin exhibits a stronger antilipolytic effect and higher receptor affinity in subcutaneous compared to omental adipose tissue, highlighting regional differences in insulin action.
Bolinder et al. (1983) conducted an observational in Healthy nonobese subjects undergoing elective abdominal surgery (n=16). Insulin (in vitro) vs. Omental vs subcutaneous adipose tissue was evaluated on Sensitivity of the antilipolytic effect of insulin (half-maximal effect in microU/ml) (p=<0.01). Insulin exhibited a more sensitive antilipolytic effect in subcutaneous compared to omental adipose tissue (half-maximal effect 1 vs 3 microU/ml, P<0.01) due to higher receptor affinity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: