Key result
CHF and senile asthenia syndrome linked to higher central aortic pressure in hypertensive patients ≥80 years.
Why the study?
To evaluate the parameters of central aortic pressure in patients with arterial hypertension depending on the presence of chronic heart failure and senile asthenia syndrome.
Cross-Sectional (n=320)
In octogenarians with arterial hypertension, the presence of chronic heart failure and senile asthenia syndrome is associated with increased central aortic pressure and pronounced disturbances in vascular elasticity.
No immediate management change in octogenarian hypertensives; leaves open whether central pressure monitoring improves outcomes in those with heart failure and frailty.
Objective: to evaluate the parameters of central aortic pressure in patients with arterial hypertension (AH) depending on the presence of chronic heart failure (CHF) and senile asthenia syndrome (SSA). Materials and methods: 320 patients with AH were divided into four groups: group 1A — patients with AH, SSA and CHF (n=84), group 1B — patients with AH, SSA without CHF (n=84), group 2A — patients with AH, CHF without SSA (n=77), group 2B — patients with AH without CHF and without SSA (n=75). Central aortic pressure parameters were determined using a BPLab ABPM device using Vasotens technology (“Petr Telegin”, Nizhny Novgorod). To process the obtained data, statistical programs STATISTICA 12.0, SPSS 21.0, MedCalc 9.3.5.0 were used. Results: in patients with AH, CHF and SSA, higher average daily values of SBP ao were recorded compared to both patients with AH and CHF without SSA (p=0.004) and with AH, SSA without CHF (p=0.019). The presence of SSA led to higher AIx ao values both in patients with hypertension, SSA and CHF (p<0.001), and in patients with AH and SSA without CHF (p<0.001). In patients with AH and CHF, regardless of the presence of SSA, higher rates of PBP ao (p<0.001), AIx ao (p<0.001), ED (p<0.001) and lower rates of SERV (p<0.001) were recorded. When assessing the degree of influence of CHF or SSA, it was shown that CHF had a more pronounced effect on PBP ao (p<0.001), ED (p<0.001) and SERV (p<0.001) indicators than SSA. Conclusion: in patients with AH aged 80 years and older, the development of both SSA and, to a greater extent, the presence of CHF was accompanied by an increase in central aortic pressure. With a combination of AH, CHF and SSA, the most pronounced disturbances in the elastic properties of blood vessels were observed, which is associated with a high cardiovascular risk.
No takes yet. Share an insight, caveat, or question.
Сафроненко et al. (2025) conducted a cross-sectional in Arterial hypertension (n=320). Presence of chronic heart failure and senile asthenia syndrome vs. Arterial hypertension without chronic heart failure and senile asthenia syndrome was evaluated on Central aortic pressure parameters (SBP ao, AIx ao, PBP ao, ED, SERV) (p=<0.001). In patients with arterial hypertension aged ≥80 years, the combination of chronic heart failure and senile asthenia syndrome was associated with significantly higher central aortic pressure (p<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: