What question did this study set out to answer?

To investigate the relationship between weather factors and negative symptom severity in schizophrenia, focusing on inflammatory responses.

From Weather to Symptoms: Preliminary Links Between Weather and Inflammation in Schizophrenia

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Observational study reveals associations between weather factors and negative symptoms in schizophrenia, suggesting inflammation plays a role.

To investigate the relationship between weather factors and negative symptom severity in schizophrenia, focusing on inflammatory responses.
Observational cross-sectional study involving 81 adults with schizophrenia across three centers.
Negative symptom severity assessed using PANSS negative subscale; meteorological data collected for each assessment from the nearest station.
Cytokine levels and general inflammatory response evaluated through principal component analysis and linear regression.
Higher relative humidity, lower temperature, and longer sunshine duration were linked to increased PANSS negative scores.
IL-1β showed the strongest association with PANSS negative symptom scores among tested cytokines.
The indirect link between humidity and negative symptoms was partly explained by a general inflammatory component.

Modzelewski et al. (2026) studied this question.

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Observational study reveals associations between weather factors and negative symptoms in schizophrenia, suggesting inflammation plays a role.